TERT structural rearrangements in metastatic pheochromocytomas

T Dwight; A Flynn; K Amarasinghe; DE Benn; R Lupat; J Li; DL Cameron; A Hogg; S Balachander; ILM Candiloro; SQ Wong; BG Robinson; AT Papenfuss; AJ Gill; A Dobrovic; RJ Hicks; RJ Clifton-Bligh; RW Tothill

Journal article

TERT structural rearrangements in metastatic pheochromocytomas

T Dwight, A Flynn, K Amarasinghe, DE Benn, R Lupat, J Li, DL Cameron, A Hogg, S Balachander, ILM Candiloro, SQ Wong, BG Robinson, AT Papenfuss, AJ Gill, A Dobrovic, RJ Hicks, RJ Clifton-Bligh, RW Tothill

Endocrine Related Cancer | BIOSCIENTIFICA LTD | Published : 2018

DOI: 10.1530/ERC-17-0306

Abstract

Pheochromocytomas (PC) and paragangliomas (PGL) are endocrine tumors for which the genetic and clinicopathological features of metastatic progression remain incompletely understood. As a result, the risk of metastasis from a primary tumor cannot be predicted. Early diagnosis of individuals at high risk of developing metastases is clinically important and the identification of new biomarkers that are predictive of metastatic potential is of high value. Activation of TERT has been associated with a number of malignant tumors, including PC/PGL. However, the mechanism of TERT activation in the majority of PC/PGL remains unclear. As TERT promoter mutations occur rarely in PC/PGL, we hypothesized ..

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University of Melbourne Researchers

Aidan Flynn Author

Jason Li Author

Ida Candiloro Author

Tony Papenfuss Author

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Grants

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (APP1108032 to R.C.B., R.W.T., T.D., D.E.B., A.J.G and APP1053792 to RJH), Hillcrest Foundation (Perpetual Trustees; T.D., D.E.B., B.G.R.), Pheo Para Alliance (T.D., R.C.B., D.E.B., B.G.R.) and the National Breast Cancer Foundation to A.D. The Olivia Newton-John Cancer Research Institute acknowledges the support of the Victorian Government Operational Infrastructure Support Program.